Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
نویسندگان
چکیده
منابع مشابه
Prevalence of Peripheral Arterial Disease in Diabetic Patients
Objective: Peripheral Arterial Disease (PAD) is a state characterized by atherosclerotic occlusive disease of lower extremities. Diabetes is the main risk factor for PAD. Material and Methods: To assess the prevalence of PAD, a cross sectional study was performed on 352 diabetic patients who referred to Yazd diabetes research center from 2007 to 2010. Vascular assessment was done by measuring ...
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OBJECTIVE Adipocyte fatty acid-binding protein (A-FABP) is a major cytoplasmic protein in adipocytes and macrophages and is closely associated with metabolic syndrome, type 2 diabetes, and atherosclerosis. Here, we investigated whether A-FABP was associated with nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes. RESEARCH DESIGN AND METHODS We enrolled 181 type 2 diabetic patients. C...
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BACKGROUND Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study therefore investigated MCP-1 in patients with PAD. METHODS Serum MCP-1 was determin...
متن کاملCirculating adipocyte fatty acid-binding protein levels are independently associated with heart failure.
A-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role in obesity-related insulin resistance, inflammation and atherosclerosis in animals. In the present study, we sought to investigate the association of A-FABP with HF (heart failure) in Chinese subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, gender- and BMI...
متن کاملClinical significance of urinary liver-type fatty acid-binding protein in patients with diabetic nephropathy.
Tubulointerstitial damage plays a crucial role in the progression of kidney diseases, including diabetic nephropathy (1). Among several distinct types of fatty acid– binding protein (FABP), liver-type FABP (L-FABP) is abundantly expressed in hepatocytes and constitutively expressed in proximal tubular cells of the kidney (2). L-FABP incorporates albumin-bound free fatty acids (FFAs) that are fi...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2020
ISSN: 2077-0383
DOI: 10.3390/jcm9092843